Table 3.
Statistics of the AP frequency of wt and NaV1.9 KO DRG neurons stimulated either with PGPC or PGPC and inflammatory soup (IS).
Steady state | Steady state | 0 pA | 20 pA | 40 pA | 60 pA |
---|---|---|---|---|---|
F(3, 27) = 3.73 | F(3, 27) = 6.14 | F(3, 27) = 7.67 | F(3, 27) = 9.66 | ||
Basal wt | PGPC wt | 0.012* | 0.0011** | 0.0018** | 0.00083*** |
Basal wt | Basal NaV1.9 KO | 1 | 1 | 0.92 | 0.69 |
Basal NaV1.9 KO | PGPC NaV1.9 KO | 0.012* | 0.012* | 0.0037** | 0.001** |
PGPC wt | PGPC NaV1.9 KO | 1 | 0.33 | 0.69 | 0.63 |
IS | IS | F(3, 20) = 1.23 | F(3, 20) = 3.62 | F(3, 20) = 4.07 | F(3, 20) = 3.79 |
Basal wt | PGPC wt | 0.24 | 0.032* | 0.012* | 0.020* |
Basal wt | Basal NaV1.9 KO | 0.52 | 0.53 | 0.81 | 0.58 |
Basal NaV1.9 KO | PGPC NaV1.9 KO | 0.78 | 0.95 | 0.94 | 0.94 |
PGPC wt | PGPC NaV1.9 KO | 0.15 | 0.013* | 0.011* | 0.018* |
Steady state | Steady state | 80 pA | 100 pA | 120 pA | |
F(3, 27) = 8.11 | F(3, 27) = 2.61 | F(3, 27) = 1.20 | |||
Basal wt | PGPC wt | 0.002** | 0.042* | 0.17 | |
Basal wt | Basal NaV1.9 KO | 0.77 | 0.93 | 0.76 | |
Basal NaV1.9 KO | PGPC NaV1.9 KO | 0.002** | 0.092 | 0.29 | |
PGPC wt | PGPC NaV1.9 KO | 0.77 | 0.64 | 0.54 | |
IS | IS | F(3, 20) = 2.89 | F(3, 20) = 2.55 | F(3, 20) = 3.065 | |
Basal wt | PGPC wt | 0.047* | 0.072 | 0.052 | |
Basal wt | Basal NaV1.9 KO | 0.56 | 0.56 | 0.5 | |
Basal NaV1.9 KO | PGPC NaV1.9 KO | 0.83 | 0.96 | 0.93 | |
PGPC wt | PGPC NaV1.9 KO | 0.028* | 0.031* | 0.02* |