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. 2018 Jan 23;9:16. doi: 10.3389/fphys.2018.00016

Figure 6.

Figure 6

Effects of IKs block on alternans during sympathetic nerve stimulation. (A) Representative recordings of optical action potentials in control conditions and following perfusion of HMR 1556 (2 μmol/L). (B) Data showing ventricular action potential duration (APD) in control conditions and during sympathetic nerve stimulation (SNS) with and without HMR 1556. (C) Relative change in APD from baseline before and after perfusion of HMR 1556. (D) Data showing the change in the alternans threshold with SNS with and without HMR 1556. (E) Relative change in the alternans threshold before and after perfusion of HMR 1556. Data taken from a 3 × 3 pixel region in the basal left ventricle. Data represent mean ± SEM. Two-way ANOVA, with Tukey's post-hoc tests; **p < 0.01, ***p < 0.001. Paired Student's t-test; **p < 0.01, ***p < 0.001. (n = 8 hearts).