Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jan 23;9:7. doi: 10.3389/fneur.2018.00007

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Sharma, Puttachary, Thippeswamy, Kanthasamy and Thippeswamy.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

(A) Seizure severity comparison between single high dose (SHD) and repeated low dose (RLD) of KA in mice during SE. Animals in RLD group showed more severe seizures and spent more time in ≥3 stage when compared to the SHD group during the 3 h of SE. Animals in both groups were given 20–30 mg/kg kainate (i.p.) (***p < 0.0001, two-way ANOVA between 1 and 719 degrees of freedom, F = 148.60, n = 30 for each group). Adopted and modified from Tse et al. (2). (B–E) An example of a 30-min EEG trace, during SE, showing inter-ictal activity that comprises of continuous epileptiform spikes and seizure cluster <12 s without any behavioral phenotype. Convulsive seizures (CS) and non-convulsive seizures (NCS) were observed throughout SE, but behavior activity was evident only during CS, i.e., stage ≥3. Expanded electroencephalography (EEG) traces of (B) are shown in panels (C–E).