Table 1.
Case Summary
| # of Cases | Avg age (years) | Breeds Included | Diagnostics Performed | Sample Used | |
|---|---|---|---|---|---|
| Diseased (11/22) | |||||
| Antemortem diagnosis | |||||
| MUO | 7 | 5.3 | YT, Mix, Chi, MP, IG, Pug | CSF, NIDP, MRI | CSF |
| Postmortem diagnosis | |||||
| NME | 1 | 2 | Pug | CSF, HP (PM) | CSF |
| GME | 1 | 4 | Malt | CSF, NIDP, MRI, HP (AM, PM) | Brain (AM) |
| ME (unspecified) | 2 | 2 | Col, MS | CSF, NIDP, MRI (1/2); HP (PM) (2/2) | Brain (PM) and CSF |
| 11 Total | |||||
| Control (11/22) | |||||
| Diagnosis | |||||
| Neoplasia | 5 | 8 | Malt, MD, Mix, Box, WC | CSF, MRI (4/5); NIDP (3/5); HP (AM) (2/5); HP (PM) (4/5) | CSF (5/5) and Brain (PM) (2/5) |
| Degenerative | 4 | 4 | BM, Mix, DP, GSD | CSF, MRI (4/4); NIDP (3/4); HP (PM) (1/4) | CSF |
| Trauma | 1 | 6 | Wei | CSF, MRI | CSF |
| Epilepsy | 1 | 10 | SP | CSF, NIDP, MRI | CSF |
| 11 Total | |||||
Diseased cases (11 of 22) represent animals diagnosed with MUO based on clinical presentation and antemortem diagnostics, with or without postmortem assessment. Antemortem diagnosis could not be further classified into the MUO subtypes. Postmortem diagnosis was made in 4 of 11 cases, two of which were diagnosed as either NME or GME and two of which had meningoencephalitis but lesions were not specific for any subset of MUO (see discussion). Control cases (11 of 22) are animals with noninflammatory CSF and either a definitive non‐MUO diagnosis or additional clinical findings inconsistent with MUO. For “Diagnostics” and “Sample Used,” if a fraction is not specified, then it applies to all in the group. MUO, meningoencephalomyelitis of unknown origin; ME, meningoencephalitis; NME, necrotizing meningoencephalitis; GME, granulomatous meningoencephalomyelitis; YT, Yorkshire Terrier; Mix, mixed breed; Chi, Chihuahua; MP, Miniature Pinscher; IG, Italian Greyhound; Malt, Maltese; Col, Collie; MS, Miniature Schnauzer; MD, Miniature Dachshund; BM, Belgian Malinois; Box, Boxer; WC, Welsh Corgi; DP, Doberman Pinscher; GSD, German Shepherd; Wei, Weimaraner; SP, Standard Poodle; CSF, cerebrospinal fluid; NIDP, negative infectious disease profile; MRI, magnetic resonance imaging; HP, histopathology; AM, antemortem; PM, postmortem.