Table 6.
Multivariable Cox proportional hazards models exploring the effect of treatment, change in an echocardiographic variable, and the value of the same variable recorded at baseline on time to the primary endpoint constructed for 4 echocardiographic variables; LVIDDN, LA/Ao, LVIDSN, and FS%
| Hazard Ratio | 95% Confidence Intervals of Hazard Ratio | P‐Value | |
|---|---|---|---|
| Change in LVIDDN model (n = 327) | |||
| Treatment (pimobendan) | 0.64 | 0.46–0.90 | 0.010 |
| LVIDDN (per 0.1 unit) | 1.30 | 1.20–1.41 | <0.0001 |
| Δ LVIDDN (per 0.1 unit change) | 1.26 | 1.11–1.43 | 0.0003 |
| Change in LA/Ao model (n = 329) | |||
| Treatment (pimobendan) | 0.63 | 0.46–0.88 | 0.0060 |
| LA/Ao (per 0.1 unit) | 1.21 | 1.15–1.28 | <0.0001 |
| Δ LA/Ao (per 0.1 unit change) | 1.14 | 1.06–1.22 | 0.0002 |
| Change in LVIDSN model (n = 327) | |||
| Treatment (pimobendan) | 0.71 | 0.51–1.00 | 0.051 |
| LVIDSN (per 0.1 unit) | 1.07 | 0.97–1.18 | 0.16 |
| Δ LVIDSN (per 0.1 unit change) | 1.22 | 1.05–1.41 | 0.0084 |
| Change in FS% model (n = 329) | |||
| Treatment (pimobendan) | 0.64 | 0.46–0.90 | 0.011 |
| FS % (per 10 units) | 1.47 | 1.16–1.85 | 0.0014 |
| Δ FS% (per 10 units change) | 1.05 | 0.77–1.44 | 0.75 |
Δ, Change in; FS%, fractional shortening; LA/Ao, left atrial‐to‐aortic root ratio; LVIDDN, normalized left ventricular internal diameter in diastole; LVIDSN, normalized left ventricular internal diameter in systole.
All P‐values that appear in bold are < 0.05.