Table 1.
Evaluation of the sub-chronic toxicity of NDAM in BALB/C mice
| Mortality | Body weight (g) Day 0 | Body weight (g) Day 28 | Body weight (g) Day 60 | Toxic Signs | ALT (U/L) | AST (U/L) | ALP (U/L) | |
|---|---|---|---|---|---|---|---|---|
| Control | None | 20.30 ± 1.10 | 23.10 ± 1.70 | 25.60 ± 1.80 | None | 75.6 ± 34.0 | 301.5 ± 53.0 | 101.7 ± 13.0 |
| LDNDAM (10 mg/kg) |
None | 19.86 ± 1.30 | 23.85 ± 1.90 | 25.80 ± 1.70 | None | 69.4 ± 39.0 | 316.0 ± 37.0 | 125.4 ± 20.4 |
| HDNDAM (50 mg/kg) |
None | 20.80 ± 1.40 | 22.50 ± 2.10 | 24.90 ± 2.30 | None | 64.5 ± 32.0 | 246.0 ± 55.0 | 113.7 ± 19.0 |
Parameters evaluated for sub-chronic toxicity test including mortality rates, body weight, toxic signs and biochemical analysis of ALT, AST and ALP
No statistically significant was observed compared to control (p < 0.05)