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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Am J Obstet Gynecol. 2017 Apr 13;217(2):216.e1–216.e13. doi: 10.1016/j.ajog.2017.04.008

Figure 3. Collagen synthesis was increased by hyperglycemia.

Figure 3

Hyperglycemia suppressed the expression of matrix metalloproteinases, MMP1 (A) and MMP13 (B). T2DM influenced the expression of TIMP1 (C), TIMP2 (D), TIMP3 (E), and TIMP4 (F). Hyperglycemia activated collagen genes, COL1A2 (G) and COL4A (H). Each experiment was repeated three times. * indicates significant difference (P < 0.05) when compared with the ND group.