Table 5.
Summary of the characterized protein phosphatases.
| Name | ID | Localization | Regulators | Substrates | Function | References |
|---|---|---|---|---|---|---|
| TgPP1 | TGME49_310700 | Cytoplasm and Nucleus | TgLRR1 | Host cell invasion; Essential in parasite growth | Delorme, V., et al. (2002); Daher, W., et al. (2007) | |
| PfPP1 | PF3D7_1414400 | Cytoplasm and Nucleus; Maurer’s clefts of infected erythrocytes | PfLRR1; PfI2; PfI3 | PfSBP1 | DNA synthesis and cell cycle progression | Bhattacharyya, M. K., et al. (2002); Kumar, R., et al. (2002); Blisnick, T., et al. (2006); Daher, W., et al. (2006); Freville, A., et al. (2012); Freeville, A., et al. (2013); Freville, A., et al. (2014); Hollin, T., et al. (2016) |
| PfPP2A | PF3D7_0925400 | PfARP; PfPTPA | Sexual stage development | Li, J. L. and D. A. Baker (1997); Dobson, S., et al. (1999); Dobson, S., et al. (2003); Vandomme, A., et al. (2014) | ||
| TgPP2B or TgCnA | TGME49_311310 | Cytoplasm and enriched in apical end for extracelluar parasites | TgCnB | Stabilize attachment of extracellular parasites to host cells | High, K. P., et al. (1994); Moudy, R., et al. (2001); Paul, A. S., et al. (2015) | |
| PfPP2B or PfCnA | PF3D7_0802800 | Cytoplasm | PfCnB | Stabilize attachment of extracellular parasites to host cells | Bell, A., et al. (1994); Berriman, M. and A. H. Fairlamb (1998); Kumar, R., et al. (2005); Singh, S., et al. (2014); Paul, A. S., et al. (2015); Philip, N. and A. P. Waters (2015) | |
| PfPP5 | PF3D7_1355500 | Cytoplasm and Nucleus | Pfhsp90 | Dobson, S., et al. (2001); Lindenthal, C. and M. Q. Klinkert (2002) | ||
| PfPP7 | PF3D7_1423300 | Cytoplasm | Dobson, S., et al. (2001) | |||
| PfPPKL | PF3D7_1466100 | Ookinete development | Guttery, D. S., et al. (2012); Philip, N., et al. (2012) | |||
| PfSLP1 | PF3D7_1469200 | Microneme Development; Ookinete development | Patzewitz, E. M., et al. (2013) | |||
| PfSLP2 | PF3D7_1206000 | The apical end of invasive merozoites and unknown vesicles | PfBand3 | Regulation of Band 3 Dynamics during Parasite Invasion | Fernandez-Pol, S., et al. (2013) | |
| PfPPM2 | PF3D7_1138500 | PfEF-1β | Gametocyte sex allocation and ookinete differentiation | Mamoun, C. B., et al. (1998); Mamoun, C. B. and D. E. Goldberg (2001); Guttery, D. S., et al. (2014) | ||
| PfPPM5 | PF3D7_0810300 | Oocyst development | Guttery, D. S., et al. (2014) | |||
| TgPPM13 | TGME49_231850 | Toxofilin | Regulation of phosphorylation status of Toxofilin | Delorme, V., et al. (2003); Jan, G., et al. (2007) | ||
| TgPPM20 or TgPP2Chn | TGME49_282055 | Rhoptries and host nucleus | Gilbert, L. A., et al. (2007) |