Table 3.
Placebo (n = 12) | Exenatide (n = 11) | |||
---|---|---|---|---|
Baseline | 3 Month | Baseline | 3 Month | |
Circumferential Strain | −23.5 ± 0.7 | −22.6 ± 1.4 | −23.7 ± 1.7 | −25.6 ± 1.78 |
Longitudinal Strain | −19.3 ± 0.7 | −18.3 ± 0.8 | −17.6 ± 1.2 | −18.5 ± 1.2 |
Stroke Volume (mL/beat) | 81.0 ± 12.8 | 80.7 ± 1.9 | 88.2 ± 3.3 | 93.3 ± 2.8 |
MV E Wave Velocity | 0.74 ± 0.06 | 0.78 ± 0.06 | 0.69 ± 0.04† | 0.61 ± 0.06† |
MV E:A Wave Velocity | 0.83 ± 0.06 | 0.82 ± 0.06 | 1.04 ± 0.13 | 0.85 ± 0.09 |
MV Deceleration Time | 283.3 ± 12.8 | 239.8 ± 14.6 | 236.0 ± 6.6 | 234.6 ± 17.0 |
Septal E’ | 0.07 ± 0.01 | 0.07 ± 0.1 | 0.08 ± 0.01 | 0.08 ± 0.01 |
Septal E:E’ | 10.4 ± 0.8 | 12.6 ± 1.4 | 9.6 ± 0.7 | 8.3 ± 0.9* |
Lateral E’ | 0.09 ± 0.01 | 0.09 ± 0.01 | 0.09 ± 0.01 | 0.09 ± 0.01 |
Lateral E:E’ | 7.6 ± 1.0 | 8.4 ± 1.2 | 8.1 ± 0.7 | 6.7 ± 0.6* |
Data are Mean ± Standard Error. Mitral Valve: MV.
P < 0.05 Different compared with placebo at same time point.
P < 0.05 Different compared with baseline within group.
P < 0.05 Main effect of drug.