Table 4. Plasma glucose levels during OGTT at each visit and changes from baseline at the end of the intervention period (8 weeks).
| Baseline |
4 weeks |
8 weeks |
12 weeks (after washout period) |
Changes from baseline to 8 weeks |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MEAN | SEM | pa | MEAN | SEM | pa | MEAN | SEM | pa | MEAN | SEM | pa | MEAN | SEM | pa | ||
| Fasting (mg/dl) | ||||||||||||||||
| Placebo group | 110.3 | 1.1 | 0.669 | 111.0 | 1.1 | 0.460 | 109.7 | 1.2 | 0.804 | 112.4 | 1.4 | 0.262 | –0.6 | 0.9 | 0.833 | |
| LcS group | 109.6 | 1.3 | 109.7 | 1.3 | 109.3 | 1.4 | 110.2 | 1.4 | –0.3 | 0.8 | ||||||
| 30-min (mg/dl) | ||||||||||||||||
| Placebo group | 181.9 | 3.2 | 0.932 | 184.0 | 3.4 | 0.541 | 184.6 | 3.2 | 0.676 | 188.4 | 3.7 | 0.356 | 2.7 | 3.1 | 0.594 | |
| LcS group | 181.5 | 3.0 | 187.1 | 3.8 | 186.6 | 3.6 | 183.9 | 3.2 | 5.1 | 3.2 | ||||||
| 1-hr (mg/dl) | ||||||||||||||||
| Placebo group | 217.9 | 3.3 | 0.853 | 213.3 | 3.9 | 0.939 | 210.2 | 6.1 | 0.713 | 213.1 | 4.7 | 0.608 | –7.7 | 5.5 | 0.582 | |
| LcS group | 218.8 | 3.7 | 213.8 | 5.2 | 207.1 b | 5.3 | 209.4 | 5.4 | –11.6 | 4.4 | ||||||
| 90-min (mg/dl) | ||||||||||||||||
| Placebo group | 199.9 | 4.6 | 0.456 | 198.6 | 4.7 | 0.372 | 194.7 | 6.3 | 0.724 | 187.1 c | 6.0 | 0.989 | –5.2 | 4.2 | 0.770 | |
| LcS group | 195.1 | 4.4 | 192.0 | 5.7 | 191.8 | 5.3 | 187.0 | 6.3 | –3.3 | 4.9 | ||||||
| 2-hr (mg/dl) | ||||||||||||||||
| Placebo group | 165.8 | 4.6 | 0.461 | 167.5 | 5.1 | 0.373 | 162.0 | 5.5 | 0.694 | 158.9 | 5.8 | 0.952 | –3.9 | 4.5 | 0.250 | |
| LcS group | 161.5 | 3.5 | 161.3 | 4.7 | 164.7 | 4.3 | 158.4 | 4.9 | 3.2 | 4.2 | ||||||
| AUC (mg/dl·h) | ||||||||||||||||
| Placebo group | 368.9 | 5.1 | 0.642 | 367.6 | 5.7 | 0.705 | 362.7 | 8.0 | 0.893 | 362.1 | 6.9 | 0.634 | –6.2 | 5.4 | 0.791 | |
| LcS group | 365.5 | 5.2 | 364.2 | 6.8 | 361.3 | 6.4 | 357.3 | 7.4 | –4.2 | 5.3 | ||||||
OGTT: oral glucose tolerance test; LcS: L. casei strain Shirota YIT 9029.
ap values analysed by the unpaired Student’s t-test.
b, cMean values were significantly different from those at baseline (paired Student’s t-test with Bonferroni-Holm adjustment). The p values were as follows: bp=0.036; cp=0.019.