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. 2017 Dec 9;9(1):1091–1106. doi: 10.18632/oncotarget.23124

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Copyright: © 2018 Kim et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A) wCOXEN and bCOXEN of final paclitaxel biomarkers in breast cancer and ovarian cancer cohorts: a red boxplot represents an ovarian cancer cohort, UVA-51, with significantly poor bCOXEN distribution, indicating unfitted for cross-cancer prediction. (B) Kaplan-Meier (KM) survival curves were calculated in predicted-positive (responsive) and predicted-negative (nonresponsive) groups of patients after outcome stratification in ovarian cancer cohorts and there are significant survival difference between the two groups in TCGA-388 (log rank-test p=0.011) and (C) Dressman-199 cohort (p=0.041) (D) but not in UVA-51 cohort (p=0.734) (E) positive predictive value of paclitaxel predictor (green) and pathological complete response rate (red) in breast cancer and ovarian cancer cohorts (^** p<0.05, ^***p < 0.01).