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. 2017 Nov 9;9(1):122–141. doi: 10.18632/oncotarget.22343

Figure 5. Residue interaction networks.

Figure 5

A. RINs of the active functional extracellular domain residues of PROM1 position in the wild type and B. the L245P mutant forms. Wild type reported on H-bond with Glu249 and no closely atomic interaction with the surrounding residues. L245P mutant form shows two H-bond interaction with Leu248, Glu249, and several closer atomic interactions generated through Pro245 with Ile241, His242, Asn69, Val73, and Leu248. The more interactions between the L245P mutant and neighboring residues could be destabilized at the bHLH-Zip domain in 130 ns.