Table 3. Subgroup analysis of the association between HDP and ASD.
Studies | OR | 95% CI | |
---|---|---|---|
Clinical classification | |||
Gestational hypertension | 9 | 1.37 | 1.21–1.54 |
Pre-eclampsia | 11 | 1.43 | 1.31–1.55 |
Chronic hypertension complicating pregnancy | 4 | 1.48 | 1.29–1.70 |
Mixed | 3 | 1.37 | 1.13–1.67 |
Maternal age | |||
Higher in the case group | 7 | 1.44 | 1.33–1.55 |
Match between case and control | 7 | 1.29 | 1.11–1.50 |
Lower in the control group | 2 | 1.42 | 1.16–1.73 |
Not mentioned | 4 | 1.50 | 1.22–1.84 |
Preterm birth | |||
Higher rate in the case group | 7 | 1.41 | 1.22–1.63 |
Match between case and control | 3 | 1.78 | 1.33–2.37 |
Higher rate in the control group | 1 | 1 | 0.51–1.95 |
Not mentioned | 10 | 1.41 | 1.32–1.51 |
Premature rupture of membranes | |||
Higher rate in the case group | 1 | 0.82 | 0.18–3.76 |
Match between case and control | 3 | 0.92 | 0.66–1.28 |
Higher rate in the control group | 1 | 1 | 0.51–1.95 |
Not mentioned | 16 | 1.45 | 1.36–1.54 |
Maternal education | |||
Higher in the case group | 1 | 3.65 | 1.08–12.35 |
Match between case and control | 3 | 1.90 | 1.57–2.31 |
Higher in the control group | 2 | 1.26 | 0.80–1.99 |
Not mentioned | 15 | 1.38 | 1.30–1.47 |
Geographic area | |||
Asia | 3 | 1.18 | 0.70–1.99 |
America | 10 | 1.45 | 1.36–1.54 |
Europe | 6 | 1.46 | 1.16–1.84 |
Africa | 1 | 1.78 | 0.40–7.90 |
Oceania | 2 | 1.17 | 0.94–1.45 |
Gender of participants | |||
Male/female higher in case group | 8 | 1.38 | 1.29–1.48 |
Match | 9 | 1.68 | 1.42–1.99 |
Male/female higher in control group | 0 | - | - |
Not mentioned | 4 | 1.44 | 1.19–1.74 |
The mixed group include pre-eclampsia, gestational hypertension and chronic hypertension complicating pregnancy.