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. 2017 Nov 22;9(1):1403–1425. doi: 10.18632/oncotarget.22608

Figure 3. Mechanisms of lncRNAs in TC progression.

Figure 3

(A) silencing of PVT1 represses proliferation and decreases cyclin D1 expression through reducing recruitment of EZH2 and modulating TSHR; (B) down-regulated PTCSC3 promotes cell growth and inhibits apoptosis; (C) BANCR overexpression inhibits cell proliferation and invasion, and induces apoptosis through inactivation of ERK and p38 in PTC cell lines (TPC-1, K1, and BCPAP); (D) FAL1 can reduce the expression of CDKN1A via binding to BMI1, thus promoting proliferation and migration; (E) NEAT1 promotes migration and invasion, as well as increases the expression of β-catenin through the reduction of miR-214; (F) downregulation of NAMA inhibits apoptosis via modulating Raf- MEK-ERK signaling pathway; (G) down-regulated GAS8-AS1 promotes cell viability; (H) MALAT1 promotes proliferation and invasion by up-regulating the expression of IQGAP1 in FTC.