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. 2017 Nov 22;9(1):1403–1425. doi: 10.18632/oncotarget.22608

Figure 4. Mechanisms of lncRNAs in TSCC progression.

Figure 4

(A) down-regulated MEG3 results in miR-26a overexpression, and then reduce DNMT3B expression, thus promoting cell proliferation and inhibiting apoptosis; (B) MALAT1 overexpression promotes tumor growth and invasion by increasing JAG1 expression resulted from the reduction of miR-124; induces EMT; (C) down-regulated NKILA promotes tumor cell migration and invasion via promoting IκBα phosphorylation induced by IKK, NF-κB activation and the induction of EMT process; (D) UCA1 promotes migration; (E) LINC00673 promotes migration and invasion.