Table 2. Databases used for circRNAs detection in cancers tissues and cells.
| Databases | De novo? | Characteristics | URL | Refs |
|---|---|---|---|---|
| CircNet | No | Tissue-specific circRNA expression profiles; Integrated CiRNA-miRNA -mRNA networks. |
http://circnet.mbc.nctu.edu.tw/ | [29] |
| CIRCexplorer | No | Depending on the mapping strategy of aligners; CircRNAs annotation only. |
http://yanglab.github.io/CIRCexplorer/ | [41] |
| UROBORUS | No | Total RNA-seq data with no poly(A) depletion or RNase R treatment; Detecting lower expressed circRNAs; Lower false positive rate. |
http://uroborus.openbioinformatics.org/en/latest/ | [46] |
| Acfs | Yes | Quantification and fast; Highest F1 accuracy; Lowest false discovery rate; Identify fusion circRNAs. |
https://github.com/arthuryxt/acfs | [87] |
| Circ-Seq | No | Genomic annotation; Fully automated; Running in a multi-threaded cluster. |
http://bioinformaticstools.mayo.edu/research/circ-seq/ | [102] |
| circBase | No | Downloading freely the merged and unified data sets of circRNAs | http://www.circbase.org/ | [103] |
| Circ2Traits | No | A disease-circRNA association database Identifying diseases associated SNPs on circRNAs loci |
http://gyanxet-beta.com/circdb/ | [104] |
| starBase v2.0 | No | Providing comprehensive circRNA–miRNA-mRNA and protein–circRNA interaction networks | http://starbase.sysu.edu.cn/ | [105] |