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. 2017 Jul 4;9(1):236–248. doi: 10.18632/oncotarget.18959

Figure 4. TLR4 expression.

Figure 4

(A) TLR4 gene expression, relative to SCC72, showed significant difference between SCC90 and the other cell lines; no significant differences between both HPVs- and both HPVs+, by qPCR (target gene normalized to U6) (**p < 0.0001; Mean ± SEM); (B) Median Fluorescence intensity (MFI) showed no significant difference between cell lines, by flow cytometry (Mean ± SD); (C) TLR4 expression, relative to SCC72, between non stimulated cells and cells stimulated with LPS: significant higher difference between SCC72 and SCC2 (*p < 0.01; mean ± SEM); (D) TLR4 expression between non stimulated cells and cells stimulated with LPS ultra pure (LPS-UP): significant difference between SCC89 and the other cell lines (*p < 0.01; mean ± SEM); (E) anti-TLR4 stain in HPV– tumors and HPV+ tumors: Lower expression of TLR4 in HPV-associated OPSCC; (F) Box and whisker plot of TLR4 stain in HPV– and HPV+ OPSCC: significantly higher stain in HPV– tumors (p < 0.0001).