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. 2017 Dec 5;9(1):249–267. doi: 10.18632/oncotarget.22922

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Copyright: © 2018 Ham et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A) Treatment of CXCR4⁺TNBC:CAFs co-culture spheroids with AMD3100 (CXCR4 antagonist) normalizes proliferation to level of the CXCR4⁺TNBC:HMF co-culture. (B) Treating CXCR4⁺TNBC:HMF co-culture spheroids with CXCL12-containing conditioned medium from CAFs stimulates proliferation to that of CXCR4⁺TNBC:CAF co-culture spheroids.