Figure 1. Mutational trinucleotide signatures in the series of 20 ASCCs.

Mutational trinucleotide signatures were determined by approaches described in the Materials and Methods section.¹⁸ Signature 1A (Age) is characterized by C>T in ACG, CCG, GCG or TCG; signature 2 (APOBEC) by C>T and C>G in TCA or TCT ; signature 7 (UV) by C>T in TCG; and signatures 10 (POLE mutation ) by C>T in TCG and C>A in TCT. Signature R2 is not validated.