Table 1. General functions of RCAN1.

Experimental condition	CaN interaction/ activity	Cells/species	Affected phenotypes	References
In vitro & In vivo	+	U2OS, COS-7, CHO, PC12, HEK293 Rat myocyte, mouse		[33, 37-41]
In vitro		HA-1	Cell proliferation	[42]
In vivo	+	S. cerevisiae		[121]
In vitro & In vivo	+	C2C12 Mouse myocyte	Cardiac hypertrophy	[43-44]
In vitro	+	C2C12		[133]
In vitro	+	HA-1 PC12	Cell death Cell proliferation	[130]
In vivo	+	Drosophila	Learning deficits	[26]
In vitro & In vivo	+	COS-7, CHO SH-SY5Y Mouse brain		[134]
In vivo	+	C. elegans	Calcineurin-deficient phenotypes: growth inhibition, small body size	[24]
In vitro & In vivo	+	BHK Mouse	Cell death	[135-136]
In vivo	+	Mouse	Cardiac hypertrophy	[137]
In vivo	+	Yeast		[21]
In vitro	+	E6-1	Cytokine expression	[138]