Table 2. Correlation of PD-L1 and PD-L2 methylation and mRNA expression with immune cell infiltrates.

Analyte	B cells		T cells (CD4+)		T cells (CD8+)		Dendritic cells
	Spearman’s ρ	p-value	Spearman’s ρ	p-value	Spearman’s ρ	p-value	Spearman’s ρ	p-value
PD-L1 mRNA	0.086	0.051	0.359	<0.001	0.420	<0.001	0.545	<0.001
PD-L2 mRNA	0.093	0.036	0.398	<0.001	0.399	<0.001	0.624	<0.001
cg15837913 (PD-L1)	0.024	0.59	0.007	0.88	–0.197	<0.001	–0.086	0.052
cg02823866 (PD-L1)	0.093	0.036	0.010	0.82	–0.020	0.64	–0.020	0.65
cg14305799 (PD-L1)	-0.071	0.11	–0.111	0.012	–0.122	0.006	–0.112	0.011
cg13474877 (PD-L1)	-0.034	0.44	–0.079	0.073	–0.166	<0.001	–0.129	0.003
cg19724470 (PD-L1)	0.099	0.025	–0.010	0.83	–0.136	0.002	–0.079	0.073
cg14440664 (PD-L2)	0.394	<0.001	0.340	<0.001	0.326	<0.001	0.275	<0.001
cg07211259 (PD-L2)	0.091	0.040	0.053	0.23	–0.065	0.14	–0.008	0.86

Spearman’s correlation (ρ, p-value) between PD-L1 and PD-L2 promoter methylation together with PD-L1 and PD-L2 mRNA expression and immune cell infiltrates. Immune cell infiltrates were determined using RNA-Seq based quantification as shown by Li et al. [22].