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. 2017 Dec 7;9(1):668–679. doi: 10.18632/oncotarget.23089

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Copyright: © 2018 Chen et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A) Verteporfin inhibited the proliferation activity of CAL27 cell lines. (B) The cell cycle of CAL27 cells treated with Verteporfin arrested in S phase. (C) The proportion of early and late apoptosis cells increased after Verteporfin treatment. (D) The mRNA expression level of BCL-2 and C-MYC decreased after Verteporfin treatment, along with YAP target gene CTGF and CYR61. (E) The expression of BCL-2 and C-MYC proteins decreased with the increase of Verteporfin concentration. The presented columns are given as the means ± SD. ^*p < 0.05, ^**P < 0.01, ^***p < 0.001.