Figure 1. COX-2 is increased in Nf2-deficient mouse model of neurofibromatosis type 2.
(A) Western blot analysis of COX-2 and Merlin in whole tissue lysate of tumor-forming trigeminal ganglia tissue of 6-month old Nf2f/f;PostnCre- or Nf2f/f;PostnCre+ mice. (B) Relative PTGS2 gene expression in trigeminal ganglia tissue of 6-8 month old Nf2f/f;PostnCre- or Nf2f/f;PostnCre+ mice by qPCR. (** P=.004).