Table 4. Associations between genotypes and grade ≥ 2 RP.
| Parameter | Patients | Number of | Percent of | Univariate Analysis | Multivariate Analysisa | ||||
|---|---|---|---|---|---|---|---|---|---|
| (Variable) | RPs (n = 57) | Patients with RP | HR | 95% CI | p | AHR | 95% CI | p | |
| ERCC1 rs11615 (T354C; Asn118Asn)b | |||||||||
| CC | 85 | 37 | 43.5% | 1.0 | 1.0 | ||||
| CT | 59 | 17 | 28.8% | 0.531 | 0.299–0.943 | 0.031 | 0.465 | 0.261–0.921 | 0.027 |
| TT | 5 | 3 | 60.0% | 1.130 | 0.348–3.665 | 0.839 | 0.759 | 0.186–3.096 | 0.701 |
| CT or TT | 64 | 20 | 31.2% | 0.576 | 0.334–0.994 | 0.048 | 0.517 | 0.285–0.939 | 0.030 |
| ERCC1 rs3212986 (C1516A; Gln504Lys)b | |||||||||
| CC | 69 | 27 | 39.1% | 1.0 | 1.0 | ||||
| AC | 65 | 26 | 40.0% | 1.049 | 0.612–1.798 | 0.861 | 0.906 | 0.481–1.708 | 0.761 |
| CC | 15 | 4 | 36.7% | 0.639 | 0.224–1.827 | 0.403 | 0.774 | 0.251–2.388 | 0.656 |
| AC or CC | 80 | 30 | 37.5% | 0.966 | 0.574–1.626 | 0.897 | 0.869 | 0.422–1.789 | 0.703 |
| ERCC2 (XPD) rs13181 (A2251C; Lys751Gln)b | |||||||||
| AA | 124 | 46 | 37.1% | 1.0 | 1.0 | ||||
| AC | 25 | 11 | 44.0% | 1.241 | 0.643–2.397 | 0.520 | 1.151 | 0.559–2.371 | 0.703 |
| CC | 0 | NC | NC | NC | NC | NC | NC | NC | NC |
| AC or CC | 25 | 11 | 44.0% | 1.241 | 0.643–2.397 | 0.520 | 1.151 | 0.559–2.371 | 0.703 |
| XRCC1 rs25487 (A1196G; Gln399Arg)b | |||||||||
| GG | 87 | 36 | 41.4% | 1.0 | 1.0 | ||||
| GA | 52 | 18 | 34.6% | 0.732 | 0.416–1.290 | 0.281 | 0.670 | 0.367–1.225 | 0.194 |
| AA | 10 | 3 | 30.0% | 0.653 | 0.201–2.122 | 0.479 | 0.649 | 0.167–2.517 | 0.531 |
| GA or AA | 62 | 21 | 33.9% | 0.720 | 0.420–1.233 | 0.231 | 0.667 | 0.377–1.182 | 0.166 |
Abbreviations: RP = radiation pneumonitis; HR = hazard ratio; ERCC1 = excision repair cross-complementing group 1; ERCC2 = excision repair cross- complementing group 2; XPD = xeroderma pigmentosum group D; XRCC1 = X-ray repair cross- complementing group 1; Lys = lysine; Gln = glutamine; Arg = arginine; NC = not calculated.
a: Multivariate analyses in the table were adjusted for all factors listed in Table 3.
b: ERCC1 rs11615 or ERCC1 rs3212986 or ERCC2 rs13181 or XRCC1 rs25487 was independently entered into a multivariate model that was adjusted for all factors listed in Table 3.