. 2017 Dec 5;9(1):96–109. doi: 10.18632/oncotarget.22941

Table1. Characteristics of the studies included in the meta-analysis.

Study	Year	Ethnicity	Subgroup	Genotyping method	Case	Control	No. of cases	No. of controls	Polymorphisms	NOS
Mbarek H [24]	2011	Japanese	GWAS	GeneChip	CHB	non-HBV	458	2056	rs2856718; rs7453920	6
	2011	Japanese	First replication	Invader assay	CHB	non-HBV	606	2023
	2011	Japanese	Second replication	TaqMan	CHB	non-HBV	379	1539
	2011	Japanese	Third replication	TaqMan	CHB	non-HBV	1226	879
Hu LM [28]	2012	Chinese		TaqMan	HBV Carriers; HBV-HCC	HBV clearance	2644	1344	rs2856718; rs7453920	7
Li SP [29]	2012	Chinese	GWAS Southern	Gene Chip	HCC	HBV positive	1075	990	rs9272105	7
	2012	Chinese	GWAS Central	Gene Chip	HCC	HBV positive	500	500
	2012	Chinese	Validation 1	iPLEX/TaqMan	HCC	HBV-positive	2112	2208
	2012	Chinese	Validation 2	iPLEX/TaqMan	HCC	HBV-positive	1021	1491
	2012	Chinese	Replication	iPLEX/TaqMan	HCC	HBV-positive	1298	1026
Hu ZB [25]	2013	Chinese	GWAS	GeneChip	HBV carriers	HBV clearance	951	937	rs7453920 rs2856718	6
	2013	Chinese	Replication Ia	iPLEX	HBV carriers	HBV clearance	1248	1248	rs7453920 rs2856718
	2013	Chinese	Replication Ib	TaqMan	HBV carriers	HBV clearance	1000	1803	rs7453920 rs2856718
	2013	Chinese	Replication IIa	iPLEX	HBV carriers	HBV clearance	981	1417	rs7453920
	2013	Chinese	Replication IIb	TaqMan	HBV carriers	HBV clearance	1001	1205	rs7453920
Chen KM [30]	2013	Chinese		TaqMan	HCC	CHB	506	772	rs9275572	8
Al-Qahtani AA [31]	2014	Saudi Arabian		PCR-based genotyping/ TaqMan	HBV carriers (AsC, LC, HCC)	Healthy controls, HBV clearance	781	302, 587	rs2856718; rs7453920; rs9275572	7
Zhang X [32]	2014	Chinese		Flight mass spectrometry	HBV carriers (CHB, LC, HCC);	Healthy controls, HBV clearance	792	507, 350	rs2856718; rs9275572	8
Ji XW [33]	2014	Chinese		Real-time PCR	HBV carriers (CHB, ASCs, LC)	Healthy controls; HBV clearance	2489	1342; 327	rs2856718; rs9275319	8
Liao Y [34]	2014	Chinese		HRM	chronic HBV carriers; HCC	Healthy controls; HBV clearance	677	237, 398	rs7453920	8
Hou SH [35]	2015	Chinese		TaqMan	HBV carriers (CHB, LC, HCC)	Healthy controls; HBV clearance	310	316, 295	rs9275572	8
Hou SH [36]	2015	Chinese		TaqMan	HBV carriers (CHB, LC, HCC)	Healthy controls; HBV clearance	310	316, 295	rs9275319	8
Kim LH [37]	2015	Korean		TaqMan	CHB; HCC	Population control samples	958	2880	rs9275319	7
Wen J [38]	2015	Chinese		TaqMan	HCC	HBV persistent carriers	1507	1560	rs9272105; rs9275319	6
Liao Y [39]	2015	Chinese	Tibetans	HRM	HBV carriers	HBV clearance	422	486	rs7453920	7
Liao Y [39]		Chinese	Uygurs	HRM	HBV carriers	HBV clearance	195	235	rs7453920	7
Jiang DK [40]	2015	Chinese	Shanghai	MassARRAY/TaqMan	LC	CHB	440	1265	rs9275319	6
Jiang DK [40]		Chinese	Beijing		LC	CHB	272	1336	rs9275319	6
Liu WX [41]	2016	Chinese		Flight mass spectrometry	HBV carriers	Healthy controls; HBV clearance	396	254, 175	rs2856718; rs9275572	8
Fan JH [42]	2016	Chinese		MassARRAY	HBV carriers	Healthy controls; HBV clearance	397	238, 434	rs9275319	8
Gao X [43]	2016	Chinese		Flight mass spectrometry	HBV carriers (CHB, LC, HCC)	Healthy controls	784	507	rs2856718; rs9275572	8
Trinks [44]	2017	Argentinean	Central areas	TaqMan	HBV carriers	Healthy controls; HBV clearance	201	207, 318	rs2856718; rs7453920	8
Trinks [44]	2017	Argentinean	North-western areas	TaqMan	HBV carriers	Healthy controls; HBV clearance	200	201, 313	rs2856718; rs7453920	8
Pereira VRZB [45]	2017	Brazilian		TaqMan	CHB	Healthy controls	210	210	rs7453920	8

CHB: Chronic Hepatitis B; HBV: Hepatitis B Virus; HCC: Hepatocellular Carcinoma; LC: Liver Cirrhosis; AsC: Asymptomatic Carriers; NOS: Newcastle-Ottawa Scale.