Table 3. Main results of the meta-analysis of the association between HLA-DQ rs9275572 polymorphism and HBV infection outcomes.
Comparison | Subgroup | Allele model (A vs. G) |
Heterozygous model (AG vs. GG) |
Homozygous model (AA vs. GG) |
Recessive model (AA vs. AG+GG) |
Dominant model (AA+AG vs. GG) |
||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
OR (95%CI) | PH | PZ | OR (95%CI) | PH | PZ | OR (95%CI) | PH | PZ | OR (95%CI) | PH | PZ | OR (95%CI) | PH | PZ | ||
HBV infection vs. Control | Overall | 0.68 (0.62-0.74) | 0.11 | <0.01 | 0.73 (0.65-0.82) | 0.34 | <0.01 | 0.45 (0.37-0.56) | 0.23 | <0.01 | 0.51 (0.42-0.62) | 0.41 | <0.01 | 0.66 (0.59-0.74) | 0.21 | <0.01 |
Asian | 0.64 (0.54-0.71) | 0.34 | <0.01 | 0.68 (0.59-0.78) | 0.89 | <0.01 | 0.40 (0.31-0.52) | 0.35 | <0.01 | 0.47 (0.37-0.60) | 0.46 | <0.01 | 0.62 (0.54-0.71) | 0.55 | <0.01 | |
Caucasian | 0.78 (0.66-0.91) | -* | <0.01 | 0.89 (0.71-1.13) | -* | 0.33 | 0.56 (0.40-0.78) | -* | <0.01 | 0.59 (0.43-0.81) | -* | <0.01 | 0.80 (0.64-0.99) | -* | 0.04 | |
HBV infection vs. NC | Overall | 0.70 (0.62-0.79) | 0.61 | <0.01 | 0.65 (0.56-0.76) | 0.30 | <0.01 | 0.57 (0.44-0.76) | 0.99 | <0.01 | 0.67 (0.52-0.87) | 0.99 | <0.01 | 0.63 (0.55-0.73) | 0.47 | <0.01 |
Asian | 0.66 (0.57-0.76) | 0.91 | <0.01 | 0.59 (0.49-0.71) | 0.92 | <0.01 | 0.57 (0.39-0.82) | 0.99 | <0.01 | 0.70 (0.49-1.00) | 0.99 | 0.05 | 0.59 (0.49-0.70) | 0.94 | <0.01 | |
Caucasian | 0.78 (0.64-0.94) | -* | 0.01 | 0.82 (0.61-1.09) | -* | 0.17 | 0.58 (0.38-0.88) | -* | 0.01 | 0.65 (0.44-0.95) | -* | 0.03 | 0.76 (0.58-0.99) | -* | 0.05 | |
LC vs. CHB | Chinese | 1.34 (1.14-1.56) | 0.99 | <0.01 | 0.97 (0.80-1.18) | 0.82 | 0.76 | 1.22 (0.83-1.80) | 0.82 | 0.31 | 1.25 (0.85-1.82) | 0.73 | 0.25 | 1.00 (0.83-1.21) | 0.96 | 0.97 |
HCC vs. LC+CHB | Chinese | 0.71 (0.63-0.80) | 0.79 | <0.01 | 073 (0.64-0.84) | 0.55 | <0.01 | 0.49 (0.35-0.68) | 1.00 | <0.01 | 0.54 (0.39-0.76) | 0.99 | <0.01 | 0.69 (0.60-0.80) | 0.63 | <0.01 |
-*Because there was only one study with this genotype of rs9275572, the value could not be calculated.