Table 4. Main results of the meta-analysis of the association between HLA-DQ rs7453920 polymorphism and HBV infection outcomes.
| Comparison | Subgroup | Allele model (A vs. G) |
Heterozygous model (AG vs. GG) |
Homozygous model (AA vs. GG) |
Recessive model (AA vs. AG+GG) |
Dominant model (AA+AG vs. GG) |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR (95%CI) | PH | PZ | OR (95%CI) | PH | PZ | OR (95%CI) | PH | PZ | OR (95%CI) | PH | PZ | OR (95%CI) | PH | PZ | ||
| HBV infection vs. Control | Overall | 0.72 (0.62-0.82) | <0.01 | <0.01 | 0.76 (0.64-0.89) | <0.01 | <0.01 | 0.96 (0.82-1.12) | 0.12 | 0.58 | 0.99 (0.85-1.15) | 0.22 | 0.90 | 0.75 (0.63-0.89) | <0.01 | <0.01 |
| Asian | 0.71 (0.59-0.85) | <0.01 | <0.01 | 0.75 (0.61-0.92) | <0.01 | <0.01 | 0.91 (0.75-1.11) | 0.13 | 0.34 | 0.91 (0.75-1.11) | 0.19 | 0.38 | 0.73 (0.59-0.91) | <0.01 | <0.01 | |
| Caucasian | 0.72 (0.60-0.87) | <0.01 | <0.01 | 0.77 (0.60-1.00) | 0.13 | 0.05 | 1.04 (0.81-1.35) | 0.19 | 0.75 | 1.11 (0.88-1.44) | 0.38 | 0.39 | 0.78 (0.59-1.04) | 0.04 | 0.09 | |
| HBV infection vs. NC | Overall | 0.64 (0.40-1.02) | <0.01 | 0.06 | 0.62 (0.47-0.81) | <0.01 | <0.01 | 0.69 (0.35-1.37) | <0.01 | 0.29 | 0.79 (0.43-1.47) | <0.01 | 0.46 | 0.62 (0.45-0.85) | <0.01 | <0.01 |
| Asian | 0.55 (0.46-0.65) | 0.42 | <0.01 | 0.54 (0.40-0.73) | 0.11 | <0.01 | 0.51 (0.20-1.30) | 0.16 | 0.16 | 0.59 (0.24-1.46) | 0.17 | 0.26 | 0.54 (0.42-0.68) | 0.22 | <0.01 | |
| Caucasian | 0.76 (0.33-1.73) | <0.01 | 0.51 | 0.70 (0.45-1.08) | 0.01 | 0.10 | 0.83 (0.33-2.08) | <0.01 | 0.70 | 0.96 (0.44-2.07) | 0.01 | 0.92 | 0.72 (0.42-1.24) | <0.01 | 0.24 | |