Table 5. Main results of the meta-analysis of the association between HLA-DQ rs9275319 polymorphism and HBV infection outcomes.
| Comparison | Subgroup | Allele model (G vs. A） |
Heterozygous model (AG vs. AA） |
Homozygous model (GG vs. AA） |
Recessive model (GG vs. AG+AA） |
Dominant model (AG+GG vs. AA） |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR (95%CI) | PH | PZ | OR (95%CI) | PH | PZ | OR (95%CI) | PH | PZ | OR (95%CI) | PH | PZ | OR (95%CI) | PH | PZ | ||
| HBV infection vs. Control | Overall | 0.68 (0.62-0.74) | 0.12 | <0.01 | 0.69 (0.62-0.77) | 0.35 | <0.01 | 0.50 (0.38-0.65) | 0.16 | <0.01 | 0.55 (0.42-0.72) | 0.18 | <0.01 | 0.66 (0.60-0.74) | 0.26 | <0.01 |
| Chinese | 0.69 (0.61-0.79) | 0.06 | <0.01 | 0.66 (0.57-0.77) | 0.27 | <0.01 | 0.66 (0.42-1.03) | 0.20 | 0.07 | 0.71 (0.46-1.12) | 0.23 | 0.140 | 0.66 (0.57-0.76) | 0.13 | <0.01 | |
| Korean | 0.66 (0.8-0.76) | -* | <0.01 | 0.73 (0.62-0.86) | -* | <0.01 | 0.44 (0.31-0.62) | -* | <0.01 | 0.49 (0.35-0.68) | -* | <0.01 | 0.67 (0.57-0.78) | -* | <0.01 | |
| HBV infection vs. NC | Chinese | 0.64 (0.54-0.76) | 0.39 | <0.01 | 0.63 (0.51-0.77) | 0.78 | <0.01 | 0.52 (0.28-0.95) | 0.45 | 0.03 | 0.57 (0.37-1.04) | 0.45 | 0.07 | 0.62 (0.51-0.75) | 0.60 | <0.01 |
| HCC vs. LC+CHB | Overall | 0.99 (0.86-1.14) | 0.19 | 0.92 | 1.04 (0.44-1.21) | 0.18 | 0.67 | 0.81 (0.50-1.32) | 0.90 | 0.40 | 0.82 (0.51-1.32) | 0.88 | 0.41 | 1.01 (0.87-1.18) | 0.17 | 0.87 |
| Chinese | 1.02 (0.86-1.20) | 0.09 | 0.84 | 1.07 (0.89-1.29) | 0.09 | 0.45 | 0.73 (0.37-1.43) | 0.90 | 0.36 | 0.72 (0.37-1.42) | 0.95 | 0.35 | 1.05 (0.88-1.25) | 0.08 | 0.62 | |
| Korean | 0.94 (0.72-1.21) | -* | 0.61 | 0.93 (0.67-1.28) | -* | 0.65 | 0.91 (0.46-1.82) | -* | 0.80 | 0.93 (0.47-1.85) | -* | 0.84 | 0.93 (0.68-1.25) | -* | 0.62 | |
-*Because there was only one study with this genotype of rs9275319, the value could not be calculated.