Skip to main content
. 2017 Dec 12;9(1):969–981. doi: 10.18632/oncotarget.22867

Figure 5. Trinucleotide context of base substitutions in CACs and sporadic CRCs.

Figure 5

(A) Number of trinucleotide substitution patterns in non-hypermutated colorectal cancers. Six possible substitutions from pyrimidine bases were further subdivided into 96 patterns based on the neighboring nucleotides. The four panels represent 21 CACs, 11 sporadic CRCs sequenced in this study, 500 sporadic CRCs in a previous study, and 209 sporadic CRCs in TCGA. (B) Methylation levels and somatic C-to-T mutation rate at CpG dinucleotides. Methylation levels were obtained from the ENCODE sigmoid colon data. (C) The number of SNVs from TpT to GpT in CAC and sporadic CRC. TS, this study; GNK, Giannakis et al., 2016.