Figure 3.

Model of the tertiary structure of pLG72 and proposed mode of interaction with hDAAO. (A) Homology 3D model of pLG72 produced by I-TASSER server, i.e., pLG72-VA (Birolo et al., 2016) and (B) model produced by hybrid ab initio approach (Kato and Fukui, 2017). Proteolytic sites are shown in orange, residues modified by BS³ cross-linking reagent are shown in pink, and cross-linked K62 residue is shown in purple. (C) Model of hDAAO–pLG72 complex as predicted by ZDOCK server; pLG72 model is in blue, hDAAO dimer in brown, and cross-linked K62 (pLG72), and T182 (hDAAO) are shown in purple (Birolo et al., 2016). For details see Figure 1.