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Hippocampal memory prosthesis. (A) Hippocampal prosthesis restores memory functions by reinstating neural signals and thus bypassing damaged brain region. (B) A MIMO model serves as the computational basis of hippocampal memory prostheses. (C) A MIMO model accurately predicts CA1 (output) codes based on CA3 (input) codes in human. (D) MIMO-stimulation enhances memory functions in preclinical animal testing.
