Figure 5.

Altered phenylalanine/tyrosine metabolism (A) and altered proteolysis (B); a comparison of single metabolites including all patients with and without chronic graft versus host disease (cGVHD). [(A), upper part] The serum levels of the four metabolites phennylacetat, 3-(4-hydroxyphenyl) lactate, phenylalanine, and tyramine o-sulfate were significantly increased in cGVHD patients compared to patients without cGVHD. [(B), lower part] The serum levels of the proteolysis markers N-acetylserine, N-acetylaspartate, N-acetylasparagine, N-acetylglutamate, and 1-methylhistidine were significantly increased in cGVHD patients (marked with red) compared with patients without cGVHD (marked with green). All results are presented as the median, the 25%/75% percentiles and the variation range; results for cGVHD patients are presented as red boxes whereas patients without cGVHD are marked with green. The metabolites and the corresponding p-values (Mann–Whitney U-test) are shown at the top of each individual figure.