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. 2018 Jan 24;12:10. doi: 10.3389/fnins.2018.00010

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Copyright © 2018 Bond, Bernhardt, Madria, Sorrentino, Scelsi and Mitchell.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of antioxidant treatment on in vivo outcome measures. Treatment group included SOD1-G93A mice given treatments to protect against oxidative stress. Control group included untreated SOD1-G93A mice. ^*p < 0.05. (A) A Mann-Whitney U-test found no statistically significant difference between the mean onset dates of the control compared to the treatment (p > 0.05; n = number of mice). (B) A Mann Whitney U-test showed significant difference between survival dates of the treatment group vs. the control (p < 0.05). (C) Aggregated rotarod performance for SOD1-G93A mice treated with antioxidants and untreated SOD1-G93A mice (n = 139 total data points for each). ANOVA for overall treatment vs. control data (p < 0.05), t-tests for overall treatment vs. control (p < 0.05), and t-tests for treatment vs. control in each time range (in days), (p < 0.05). There is a consistent, significant difference between treatment and control rotarod performance.