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. 2018 Jan 24;9:36. doi: 10.3389/fmicb.2018.00036

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Copyright © 2018 Baksi, Kuntal and Mande.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Demonstrating the periodic microbial community patterns in the vaginal microbiome of ‘Gajer-Dataset’ used in the case study. (A) Heatmap clustered vertically based on taxa abundance and horizontally arranged based on the two community clusters (represented as ‘Cluster 1’ and ‘Cluster 2’) identified by TIME. (B) Trend plots of the constituent taxa with the plot background highlighted corresponding to the ‘community state’ affiliation (in ‘blue’ and ‘orange’) of the respective time points. (C) Demonstrating the antagonistic behavior between the two genera Lactobacillus iners and Atopobium in the vaginal microbiome dataset used in the case study generated using ‘Workflow-2.’