Figure 8.

Main alterations in the purinergic system of microglial cells in conditions of elevated pressure. The exposure of microglial cells to elevated pressure changes several players of the purinergic system in microglia, including enzymes, receptors, and transporters. Color code: red means increased levels, expression, or density; blue means decreased expression, density, or activity; and yellow means no changes at elevated pressure when compared with control pressure. Taking into account the lack of CD73 in BV-2 cells, the enzyme responsible for converting AMP into adenosine was not identified; it could be for instance alkaline phosphatase (AP), but we did not assess it experimentally. Adenosine triphosphate (ATP), adenosine monophosphate (AMP), adenosine deaminase (ADA), adenosine kinase (ADK), adenosine A₁ receptor (A₁R), adenosine A₃ receptor (A₃R), concentrative nucleoside transporter 2 (CNT2), equilibrative nucleoside transporter 2 (ENT2).