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NE-induced contraction in 2 months-old (solid bars) and 18 months-old (open bars) male (A) and female (B) aortas from vehicle- and ISO-treated mice. Values are means ± SEM; n = 6–8 vasoreactivity assays. ISO doses were 5, 40, 80, and 160 μg/g/d for 7 days. ISO, isoproterenol. *p < 0.05 vs. vehicle same group; &p < 0.05 vs. male same age and dose; #p < 0.05 vs. young same sex and dose determined by two-way ANOVA and post hoc tests.
