Table 2.
Body weight and ventricular weight/body weight ratio from young (2 months) and old (18 months) male and female mice treated with isoproterenol.
| Young (2 months old) | Old (18 months old) | |||||
|---|---|---|---|---|---|---|
| Initial BW (g) | Final BW (g) | VW/BW ratio | Initial BW (g) | Final BW (g) | VW/BW ratio | |
| MALES | ||||||
| Vehicle | 26.32 ± 0.65 | 26.65 ± 0.55 | 4.7 ± 0.06 | 31.06 ± 1.15& | 30.86 ± 0.71& | 5.0 ± 0.07 |
| ISO 5 μg/g/d | 26.06 ± 0.74 | 26.53 ± 0.66 | 5.2 ± 0.09# | 30.77 ± 0.98& | 30.00 ± 0.70& | 6.0 ± 0.13# |
| ISO 40 μg/g/d | 26.07 ± 0.48 | 25.90 ± 0.67 | 5.8 ± 0.06# | 34.09 ± 1.23& | 33.36 ± 1.02& | 5.7 ± 0.07# |
| ISO 80 μg/g/d | 26.79 ± 0.65 | 26.60 ± 0.72 | 5.8 ± 0.09# | 32.15 ± 0.91& | 30.35 ± 0.93& | 5.8 ± 0.07# |
| ISO 160 μg/g/d | 27.42 ± 0.89 | 26.92 ± 1.03 | 5.9 ± 0.10# | 32.25 ± 0.74& | 30.47 ± 0.67& | 6.0 ± 0.12# |
| FEMALES | ||||||
| Vehicle | 21.94 ± 0.44* | 21.95 ± 0.52* | 4.4 ± 0.08 | 27.79 ± 0.57& | 26.93 ± 0.66*& | 4.1 ± 0.12* |
| ISO 5 μg/g/d | 21.91 ± 0.73* | 22.38 ± 0.85* | 5.5 ± 0.07# | 27.58 ± 0.49& | 27.30 ± 0.48& | 4.7 ± 0.08# |
| ISO 40 μg/g/d | 20.83 ± 0.90* | 21.61 ± 1.00* | 5.6 ± 0.11# | 27.69 ± 1.08*& | 25.36 ± 0.82*& | 5.1 ± 0.09# |
| ISO 80 μg/g/d | 20.97 ± 1.00* | 21.62 ± 0.88* | 5.7 ± 0.11# | 28.54 ± 1.01*& | 26.59 ± 1.14*& | 5.3 ± 0.14# |
| ISO 160 μg/g/d | 21.44 ± 0.56* | 21.21 ± 0.72* | 6.1 ± 0.07# | 28.70 ± 1.11& | 26.52 ± 0.88*& | 5.4 ± 0.08# |
Values are means ± SEM, n = 4 mice. ISO doses were 5, 40, 80 and 160 μg/g/d for 7 days. BW, body weight; VW, ventricular weight; ISO, isoproterenol.
#
p < 0.05 vs. vehicle same group;
*
p < 0.05 vs. male same age and dose;
&
p < 0.05 vs. young same sex and dose determined by one- (VW/BW ratio) and two-way ANOVA (BW) and post hoc tests.