Fig. 1.

Exercise had the largest effect on cortical bone architecture in adult mice.

Cortical bone architecture was measured at the mid-diaphysis of the tibia using micro-CT analysis. The moment of inertia was calculated along the anterior–posterior axis. Significant main factor effects are noted for age (A*), exercise (E*), and their interaction (ExA*). Tukey post hoc analysis between sedentary and exercise with a p-value < 0.05 are noted by ‘*’, while student t-tests between baseline groups with a p-value < 0.05 are noted by ‘c’. Mean ± std. are shown (n = 10).