Table 4.
Univariate and multivariate analysis of baseline characteristics regarding the risk of death during follow-up in all patients
| Variables |
Univariate |
Multivariate |
||
| HR (95%CI) | P value | HR (95%CI) | P value | |
| Age (yr) | 1.042 (1.026-1.056) | < 0.001 | 1.035 (1.016-1.054) | < 0.001 |
| HCV etiology | 1.99 (1.385-2.865) | < 0.001 | ||
| Diabetes mellitus | 1.583 (1.097-2.283) | 0.010 | ||
| Active alcohol intake | 0.353 (0.230-0.542) | < 0.001 | 0.568 (0.345-0.935) | 0.020 |
| Child-Pugh score | 1.170 (1.041-1.317) | 0.008 | 1.263 (1.113-1.432) | < 0.001 |
| MELD score | 1.036 (1.007-1.066) | 0.010 | ||
| Previous decompensation | 2.33 (1.473-3.690) | < 0.001 | ||
| Previous ascites | 2.50 (1.620-3.860) | < 0.001 | ||
| Previous encepalophathy | 2.794 (1.908-4.092) | < 0.001 | 2.216 (1.493-3.290) | < 0.001 |
| Hepatocellular carcinoma | 2.872 (1.097-4.817) | < 0.001 | 2.381 (1.411-4.018) | < 0.001 |
| Previous β-blockers | 1.727 (1.194-2.498) | 0.004 | ||
| Previous diuretics | 1.957 (1.334-2.869) | 0.001 | ||
| Serum creatinine (μmol/L) | 1.006 (1.004-1.008) | < 0.001 | 1.005 (1.002-1.007) | < 0.001 |
| Serum urea (mmol/L) | 1.026 (1.013-1.040) | < 0.001 | ||
| Platelet count (× 109/L) | 0.997 (0.995-1.00) | 0.032 | ||
| TLR4 polymorphisms | 1.372 (0.770-2.445) | 0.280 | ||
HCV: Hepatitis C virus; MELD: Model for end-stage liver disease.