Figure 1.

Structural comparison of lipoxygenases from various kingdoms. In A, SLO was selected as the representative for plant lipoxygenases, whereas in B, the human 5-LO isoenzyme is shown. The structures correspond to the Protein Data Bank entries 3PZW (A), 3O8Y (B), 4G32 (C), and 5FNO (D). The structurally conserved lipoxygenase fold of the catalytic domain is colored light blue; the catalytic metal is shown as dark gray in all cases. For both plants and animals, the N-terminal PLAT domain is colored in wheat (A and B). Bacterial and fungal enzymes do not contain a PLAT domain, but the resolved N-terminal amino acid is shown as wheat spheres. In C, the bacterial enzymes have additional α helices, as colored in pale green.