Table 1.

Validated hits deriving from primary screening

HIT	Positive siRNA no.	Statistical significancea	Normalized F508del-CFTR activity		Uniprot accession no.
			Mean	S.E.
ALOX5AP	1	*	1.302	0.04	P20292
ANXA11	1	*	1.307	0.031	P50995
CDK6	1	**	1.342	0.065	Q00534
CHD4	3	***	1.787	0.095	Q14839
CNTN1	1	*	1.309	0.026	Q12860
CSNK2A1	2	*	1.395	0.021	P68400
FAU	2	***	1.621	0.066	P62861/P35544
FRAG1	2	*	1.382	0.034	Q9UHJ9
GALK1	1	*	1.304	0.022	P51570
GJA5	1	**	1.346	0.019	P36382
GJB4	1	*	1.293	0.029	Q9NTQ9
GPR149	1	***	1.445	0.078	Q86SP6
KCTD8	1	***	1.4	0.036	Q6ZWB6
LRRC59	1	**	1.37	0.039	Q96AG4
MLLT6	1	***	1.501	0.076	P55198
NR2E3	1	***	1.419	0.029	Q9Y5X4
P2RX1	1	*	1.291	0.038	P51575
PHF12	2	***	1.49	0.074	Q96QT6
PLXNA1	2	***	1.484	0.041	Q9UIW2
PLXND1	1	*	1.295	0.021	Q9Y4D7
PRPS1	1	*	1.322	0.023	P60891
PTCH1	1	***	1.425	0.029	Q13635
RARA	1	*	1.31	0.022	P10276
RBBP6	1	***	1.472	0.033	Q7Z6E9
RNF207	1	***	1.449	0.056	Q6ZRF8
RORB	1	*	1.328	0.023	Q92753
SEC22B	1	**	1.365	0.014	O75396
SGK223	1	***	1.411	0.037	Q86YV5
SLC25A1	2	*	1.303	0.021	P53007
SNRNP25	1	***	1.519	0.072	Q9BV90
TLR7	2	*	1.376	0.032	Q9NYK1
TRIM24	2	***	1.739	0.089	O15164
UBA2	2	***	1.653	0.029	Q9UBT2
UBA52	3	***	1.922	0.162	P62987
UBE2C	2	*	1.357	0.044	O00762
UBE2I	2	*	1.639	0.047	P63279
UBXN6	1	**	1.366	0.022	Q9BZV1

^a Asterisks indicate statistical significance versus respective NT-siRNA:

***, p < 0.001; **, p < 0.01; and *, p < 0.05.