Table 4.
Multivariate analysis of regional recurrence free survival (RRFS) and disease specific survival (DSS):
| Regional Recurrence Free Survival | Disease Specific Survival | |||||||
|---|---|---|---|---|---|---|---|---|
| Factor (n) | Coefficient | Wald Chi-Squared | p value | Risk Ratio (95% CI) | Coefficient | Wald Chi-Squared | p value | Risk Ratio (95% CI) |
| Gender Male (69) Female (39) |
0.70 | 0.000 | 0.997 | 1.00 (0.25–3.97) | 0.60 | 3.02 | 0.082 | 2.85 (0.86–9.27) |
| Age | 0.02 | 0.058 | 0.810 | 1.01 (0.96–1.05) | 0.02 | 1.63 | 0.202 | 1.03 (0.99–1.07) |
| Primary site Oral cavity (77) Oropharynx (24) |
1.32 | 1.86 | 0.17 | 0.166 (0.013–2.189) | 1.04 | 0.005 | 0.95 | 0.932 (0.12–7.15) |
| Primary T Stage <T3 (71) ≥ T3 (37) |
0.88 | 0.880 | 0.495 | 0.55 (0.10–3.08) | 0.60 | 1.25 | 0.263 | 1.95 (0.61–6.27) |
| Bilateral Neck Disease No (93) Yes (15) |
0.91 | 0.500 | 0.479 | 1.90 (0.32–11.18) | 0.95 | 3.37 | 0.066 | 0.18 (0.03–1.13) |
| Number of Positive nodes: 1–2 (72) >2 (36) |
0.11 | 1.094 | 0.295 | 1.12 (0.91–1.39) | 0.08 | 4.97 | 0.026 | 1.21 (1.02–1.42) |
| Extracapsular extension No (70) Yes (38) |
0.80 | 1.69 | 0.194 | 2.82 (0.59–13.45) | 0.62 | 0.27 | 0.605 | 0.72 (0.21–2.46) |
| Margins on primary site Negative (96) Positive (12) |
0.99 | 0.80 | 0.371 | 2.42 (0.35–16.84) | 0.62 | 10.76 | 0.001 | 7.60 (2.26–25.54) |
| Perineural Invasion No (65) Yes (43) |
0.78 | 1.11 | 0.292 | 2.28 (0.49–10.52) | 0.55 | 2.18 | 0.140 | 2.25 (0.77–6.57) |
| Lymphovascular Invasion No (70) Yes (38) |
0.84 | 2.99 | 0.084 | 0.24 (0.05–1.21) | 0.55 | 0.90 | 0.344 | 0.59 (0.20–1.75) |
| Adjuvant Treatments Yes (95) No (13) |
0.83 | 6.51 | 0.011 | 0.12 (0.02–0.61) | 0.61 | 12.79 | 0.000 | 0.12 (0.04–0.38) |