Expression of snoRNAs in the DLK-DIO3 and SNURF/SNRPN loci. (A) Organization of the DLK-DIO3 locus. Maternally expressed genes (open boxes) and paternally expressed genes (filled boxes) are shown. The miRNA cluster contains 54 miRNAs. (B) Normalized read counts for SNORD113-6 are shown; its expression is representative of other SNORDs in this locus. Significance was determined by 1-way ANOVA followed by Tukey multiple comparisons test. (C) Organization of the human SNURF-SNRPN locus (drawing is not to scale). Paternally expressed genes, including SNORDs, are shown as ▪, and maternally expressed genes are shown as □. (D) Normalized read counts for SNORD116-1, representative of SNORDs in the SNURF-SNRPN locus, are shown. ****P < .0001. ns, not significant.