Fig. 1.

The growth and rifamycin B yield of different A. mediterranei strains. a Measurement of the growth curves. Bacterial dry weight was calculated every 24 h. b Measurement of the specific production of rifamycin B at different time points. Erythromycin was added into the culture medium of rifQ+ and vector+. S699, the wild type; ΔrifQ, the rifQ null mutant; rifQ+, ΔrifQ transformed with pDXM4-rifQ; vector+, ΔrifQ transformed with the blank vector. Three biological replicates were performed for each strain