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A proposed feedback model for RifQ-mediated regulation of rifamycin biosynthesis and export in A. mediterranei. At the early growth phase, RifQ represses Rif_B export, accelerating the accumulation of intracellular Rif_B. When the intracellular Rif_B concentration reaches a threshold, rifamycin B was able to inactivate RifQ by either direct binding or an unknown manner, and the export of Rif_B is remarkably promoted, reducing the intracellular concentration of Rif_B
