Fig. 8.
In vitro cellular uptake study of the UCNP-based micelles in BxPc-3 cells. Cells were treated with (a) targeted (i.e., UPG-CD326) micelles, and b nontargeted (i.e., UPG) micelles (200 μg/mL), as well as (c) the combination of free anti-human CD326 (3 × 10−6 M) and targeted micelles (i.e., blocking) for 2 h at 37 °C. Blue luminescence is from the nucleus after being stained with DAPI. Upon 980 nm irradiation, the UPGs micelles emit green luminescence from the cytoplasm of the cells treated with UPG-CD326 and UPG micelles