Table 1.
Effect of crocin on ALT, AST and sex hormones levels in mice serum following induction of aging by d-galastose
|
Test
Group |
ALT (IU/mL) | AST (IU/mL) | Testosterone (ng/dl) | DHEA-SO 4 (ng/ml) |
|---|---|---|---|---|
| Control | 135.87±21.25 | 251.16±11.05 | 15±2.68 | 40.28±3.2 |
| D-galactose (DG) | 176.25±14.55## | 335±32.66## | 5.6±3.32## | 26±9.29# |
| DG+ CR 10 mg/kg | 152.57±11.41 | 297.4±32.63 | 24.6±8.1*** | 43.2±8.31** |
| DG+ CR 20 mg/kg | 128.2±15*** | 247.5±32.57** | 30.16±4.5*** | 40.5±4.12* |
| DG+ CR 40 mg/kg | 144.28±25.28* | 307.5±53.99 | 11.16±3.53 | 27±6.21 |
| CR 40 mg/kg | 149.6±14.68 | 242.2±39.97 | 18.8±6.45 | 28.5±10.87 |
Data are expressed as mean ± SD (n=7).
#
p<0.05 and
##
p<0.01 vs control;
*
p<0.05,
**
p<0.01 and
***
p<0.001 vs d-galactose-treated animals. DG (d-galactose); CR (crocin) AST (aspartate aminotransferase); ALT (alanine amino transferase); DHEA-SO4 (dehydroepiandrosterone- sulfate).