Table 2.
Multivariate overall survival model.
| Characteristics | HR (95%CI) | p-value |
|---|---|---|
| Gene Group | <0.01 | |
| RAS WT | Reference | |
| NRAS MUT | 2.0 (1.3,2.8) | |
| KRAS MUT | 1.5 (1.2,1.8) | |
| Age at diagnosis* | 1.1 (0.9,1.2) | 0.12 |
| Gender | 0.06 | |
| Male | 1.2 (0.9,1.4) | |
| Female | Reference | |
| Race/ethnicity | 0.08 | |
| African-American | 1.5 (1.0, 2.1) | 0.03 |
| Others | 1.1 (0.7,1.6) | 0.70 |
| Caucasian | Reference | |
| Primary tumor site | 0.19 | |
| Right colon | 1.2 (0.9,1.5) | |
| Left colon | 1.1 (0.8,1.5) | |
| Rectosigmoid/rectum | Reference | |
| Synchronous metastatic disease | 0.30 | |
| Yes | 1.1 (0.9,1.3) | |
| No | Reference | |
| Extrahepatic disease | <0.01 | |
| Lung | 1.1 (0.7,1.6) | |
| Liver & Lung | 1.8 (1.2,2.7) | |
| Other location | 1.7 (1.4,2.2) | |
| Liver only | Reference | |
| HAI** | 0.8 (0.6,1.1) | 0.10 |
| Liver resection** | 0.5 (0.4,0.6) | <0.01 |
*
Hazard ratio reflects 10 years increase in age
**
HAI and liver resection were coded as time-dependent covariates in the multivariable model
WT – wild-type; MUT - mutant