TABLE 4.

Univariate and Multivariate Risk Factors for Death Among 621 Patients with Nonoropharyngeal Head and Neck Squamous Cell Cancers

Characteristic at Diagnosis	Univariate Analysis (n = 621)a		Multivariate Analysis (n = 397)a,b
	HR (95% CI)	P	aHR (95% CI)	P
Age (per 10-y increase)	1.30 (1.20-1.42)	<.001	1.45 (1.28- 1.63)	<.001
Tumor stage
T1	1.00		1.00
T2	1.61 (1.15-2.27)	.006	1.48 (0.94-2.33)	.09
T3	2.65 (1.88-3.75)	<.001	2.33 (1.44-3.76)	<.001
T4	2.81 (2.04-3.87)	<.001	2.82 (1.82-4.35)	<.001
P for trend		<.001		<.001
Nodal stage
N0	1.00		1.00
N1, N2a, N2b	1.35 (1.06-1.73)	.02	1.33 (0.96-1.85)	.08
N2c, N3	1.73 (1.27-2.36)	<.001	1.83 (1.22-2.75)	.003
P for trend		<.001		.001
Sex
Men	1.00		1.00
Women	0.90 (0.72-1.12)	.35	0.97 (0.72- 1.30)	.83
Race and ethnicity
White Non-Hispanic	1.00		1.00
Black Non-Hispanic	1.33 (1.02-1.73)	.04	0.94 (0.67-1.31)	.71
Asian Non-Hispanic	0.94 (0.70-1.26)	.67	0.90 (0.57-1.43)	.66
Any race, Hispanic	1.30 (0.93-1.82)	.13	0.88 (0.53-1.44)	.61
Current tobacco use
No	1.00		1.00
Yes	1.35 (1.04-1.75)	.02	1.16 (0.83-1.62)	.37
Current alcohol use
No	1.00		1.00
Yes	1.33 (1.03-1.72)	.03	1.40 (1.03-1.90)	.03
Tumor p16 status
Negative	1.00		–
Positive	0.80 (0.54-1.18)	.26
Tumor HPV status
Negative	1.00		–
Positive	0.93 (0.55-1.55)	.77
Anatomic site
Oral cavity	1.00		1.00
Larynx	0.69 (0.51-0.93)	.02	0.96 (0.59-1.54)	.85
Nasopharynx	0.93 (0.74-1.18)	.56	0.86 (0.62-1.19)	.36

Abbreviations: aHR, adjusted hazard ratio; CI, confidence interval; HPV, human papillomavirus; HR, hazard ratio.

^aBolding indicates statistical significance.

^bThe multivariate model was restricted to patients for whom the current tobacco-use status, the current alcohol-use status, tumor and nodal stage.