TABLE 4.
Characteristic at Diagnosis | Univariate Analysis (n = 621)a
|
Multivariate Analysis (n = 397)a,b
|
||
---|---|---|---|---|
HR (95% CI) | P | aHR (95% CI) | P | |
Age (per 10-y increase) | 1.30 (1.20-1.42) | <.001 | 1.45 (1.28- 1.63) | <.001 |
Tumor stage | ||||
T1 | 1.00 | 1.00 | ||
T2 | 1.61 (1.15-2.27) | .006 | 1.48 (0.94-2.33) | .09 |
T3 | 2.65 (1.88-3.75) | <.001 | 2.33 (1.44-3.76) | <.001 |
T4 | 2.81 (2.04-3.87) | <.001 | 2.82 (1.82-4.35) | <.001 |
P for trend | <.001 | <.001 | ||
Nodal stage | ||||
N0 | 1.00 | 1.00 | ||
N1, N2a, N2b | 1.35 (1.06-1.73) | .02 | 1.33 (0.96-1.85) | .08 |
N2c, N3 | 1.73 (1.27-2.36) | <.001 | 1.83 (1.22-2.75) | .003 |
P for trend | <.001 | .001 | ||
Sex | ||||
Men | 1.00 | 1.00 | ||
Women | 0.90 (0.72-1.12) | .35 | 0.97 (0.72- 1.30) | .83 |
Race and ethnicity | ||||
White Non-Hispanic | 1.00 | 1.00 | ||
Black Non-Hispanic | 1.33 (1.02-1.73) | .04 | 0.94 (0.67-1.31) | .71 |
Asian Non-Hispanic | 0.94 (0.70-1.26) | .67 | 0.90 (0.57-1.43) | .66 |
Any race, Hispanic | 1.30 (0.93-1.82) | .13 | 0.88 (0.53-1.44) | .61 |
Current tobacco use | ||||
No | 1.00 | 1.00 | ||
Yes | 1.35 (1.04-1.75) | .02 | 1.16 (0.83-1.62) | .37 |
Current alcohol use | ||||
No | 1.00 | 1.00 | ||
Yes | 1.33 (1.03-1.72) | .03 | 1.40 (1.03-1.90) | .03 |
Tumor p16 status | ||||
Negative | 1.00 | – | ||
Positive | 0.80 (0.54-1.18) | .26 | ||
Tumor HPV status | ||||
Negative | 1.00 | – | ||
Positive | 0.93 (0.55-1.55) | .77 | ||
Anatomic site | ||||
Oral cavity | 1.00 | 1.00 | ||
Larynx | 0.69 (0.51-0.93) | .02 | 0.96 (0.59-1.54) | .85 |
Nasopharynx | 0.93 (0.74-1.18) | .56 | 0.86 (0.62-1.19) | .36 |
Abbreviations: aHR, adjusted hazard ratio; CI, confidence interval; HPV, human papillomavirus; HR, hazard ratio.
Bolding indicates statistical significance.
The multivariate model was restricted to patients for whom the current tobacco-use status, the current alcohol-use status, tumor and nodal stage.