Table 2.
Overall 12-week Adjusted Change in Health Status Stratified by Treatment Arm
| Response | Sample size | Test if the effect of CPAP, NSO, and HLSE are the same | CPAP- HLSE | NSO - HLSE | CPAP -NSO |
|---|---|---|---|---|---|
| Mean difference in change of response (95% CI); p-value | Mean difference in change of response (95% CI); p-value | Mean difference in change of response (95% CI); p-value | |||
| MCS | HLSE: 97 CPAP: 98 NSO: 99 |
0.0102 |
2.88 (0.90, 4.87) P=0.005 |
0.48 (−1.52, 2.48) P=0.636 |
2.40 (0.40, 4.41) P=0.019 |
| PCS | HLSE: 97 CPAP: 98 NSO: 99 |
0.0011 | 0.86 (−0.77, 2.49) P=0.300 |
3.03 (1.39, 4.67) P<0.001 |
−2.17 (−3.82, −0.51) P=0.010 |
| Vitality (Primary) | HLSE: 98 CPAP: 98 NSO: 100 |
0.0865 |
2.37 (0.25, 4.49) P=0.028 |
0.89 (−1.23, 3.01) P=0.410 |
1.48 (−0.66, 3.62) P=0.175 |
| Role Physical | HLSE: 98 CPAP: 98 NSO: 99 |
0.0326 |
2.72 (0.63, 4.81) P=0.011 |
1.90 (−0.19, 4.00) P=0.075 |
0.81 (−1.30, 2.92) P=0.449 |
| Physical function (Primary) | HLSE: 97 CPAP: 98 NSO: 100 |
0.0153 | −0.34 (−2.30, 1.62) P=0.736 |
2.35 (0.38, 4.31) P=0.019 |
−2.68 (−4.66, −0.70) P=0.008 |
| Role Emotional | HLSE: 98 CPAP: 98 NSO: 99 |
0.197 | 2.11 (−0.23, 4.45) P=0.078 |
1.41 (−0.95, 3.77) P=0.240 |
0.70 (−1.68, 3.08) P=0.563 |
| Social functioning | HLSE: 98 CPAP: 98 NSO: 100 |
0.0577 |
2.30 (0.15, 4.45) P=0.036 |
2.22 (0.07, 4.38) P=0.043 |
0.08 (−2.09, 2.25) P=0.942 |
| Bodily pain | HLSE: 98 CPAP: 98 NSO: 100 |
0.0391 | 1.80 (−0.34, 3.95) P=0.099 |
2.75 (0.60, 4.91) P=0.012 |
−0.95 (−3.12, 1.22) P=0.389 |
| Mental health | HLSE: 98 CPAP: 98 NSO: 100 |
0.0138 |
2.73 (0.77, 4.70) P=0.006 |
0.41 (−1.56, 2.38) P=0.684 |
2.33 (0.34, 4.31) P=0.022 |
| General health | HLSE: 98 CPAP: 98 NSO: 100 |
0.0396 |
1.94 (0.30, 3.58) P=0.021 |
1.72 (0.08, 3.36) P=0.040 |
0.22 (−1.44, 1.87) P=0.795 |
| PHQ-9 | HLSE: 98 CPAP: 98 NSO: 100 |
0.0346 |
−1.12 (−1.97, −0.27) P=0.010 |
−0.45 (−1.30, 0.40) P=0.299 |
−0.67 (−1.52, 0.18) P=0.124 |
| Sleepiness Summary Score | HLSE: 96 CPAP: 95 NSO: 99 |
0.0017 |
−1.21 (−1.89, −0.53) P=0.001 |
−0.84 (−1.51, −0.16) P=0.016 |
−0.38 (−1.06, 0.31) P=0.278 |
*
ANCOVA Model covariate adjusts for site, presence of CHD at baseline, black race, and baseline PRO response. Categorical data represented as percentage of population and continuous data represented as mean (standard deviation). HLSE-Healthy lifestyle, sleep hygiene and education intervention; CPAP-Continuous positive airway pressure; NSO-Nocturnal supplemental oxygen. SF-36-Short Form-36; MCS-mental component score; PCS-Physical component score; PHQ-9-Patient Health Questionnaire-9. All SF-36 scores are norm-based with ranges from 0–100 with higher score representing better quality of life.